Multi-functionalized Nanoparticles for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier

Primary author: Shichao Ding
Co-author(s): Yang Song; Prashanta Dutta; Yuehe Lin
Faculty sponsor: Yuehe Lin

Primary college/unit: Voiland College of Engineering and Architecture
Campus: Pullman


The Blood-Brain Barrier (BBB) as a unique and protective organization in the human brain could prevent most drugs from reaching their target, which not only limits the therapy effect but also becomes one of the biggest challenges in drug development. At present, the scientific community has witnessed an exponential increase in utilizing nanoparticles as nanomedicine for drug delivery. In particular, there is a great interest in the BBB for brain disease treatment by using a multifunctional nanomedicine system. Therefore, researching the transport efficiency of nanoparticles across the BBB has potential meaning for directing applications to deliver drugs and imaging probes to the brain. Herein, we cocultured one-cell or three-cell BBB models and utilized to study nanoparticle transport mechanisms. Various designed nanoparticles with different sizes and functions were applied to enhance transport efficiency in vitro. All researches will provide comprehension of how various properties of nanoparticles are benefited in the BBB study, what’s more, they could usher to the development of novel nanomaterials and nanotechnology-based therapies.